UTS2, urotensin 2, 10911

N. diseases: 115; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.080 GeneticVariation group BEFREE We surveyed SNPs in the UTS2 gene in 152 Japanese subjects with Type 2 diabetes mellitus and two control Japanese cohorts: one consisting of 122 elderly subjects who met stringent criteria for being non-diabetic, including being older than 60 years of age with no evidence of diabetes (HbA(1c)<5.6%), and another 268 subjects with normal glucose tolerance. 12830381 2003
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 GeneticVariation disease BEFREE We surveyed SNPs in the UTS2 gene in 152 Japanese subjects with Type 2 diabetes mellitus and two control Japanese cohorts: one consisting of 122 elderly subjects who met stringent criteria for being non-diabetic, including being older than 60 years of age with no evidence of diabetes (HbA(1c)<5.6%), and another 268 subjects with normal glucose tolerance. 12830381 2003
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.020 GeneticVariation disease BEFREE We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. 16597476 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.580 GeneticVariation group BEFREE We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. 16597476 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE We studied expression of urotensin II and its receptor mRNAs in the tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas. 12668216 2003
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.030 AlteredExpression disease BEFREE We showed that U-II protein and mRNA levels were significantly elevated in the arteries of patients with coronary atherosclerosis in comparison to healthy arteries. 17988761 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE We investigated the expression of urotensin II and urotensin II receptor in adrenocortical and adrenomedullary tumors and the functional effects of urotensin II receptor activation. 19001524 2009
CUI: C0004096
Disease: Asthma
Asthma 		0.210 AlteredExpression disease BEFREE We found that both UII and TGF-β1 were upregulated in asthma lung tissues. 22270542 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE We found expressions of urotensin II mRNA and its receptor in 55 of 59 breast cancer tissues and in 55 of 59 normal breast tissues. 25112588 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE We found expressions of urotensin II mRNA and its receptor in 55 of 59 breast cancer tissues and in 55 of 59 normal breast tissues. 25112588 2014
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.020 GeneticVariation group BEFREE We detected a significant association between the T21M polymorphism in the UTS2 gene and migraine (53.8 % in patients, 40.4 % in controls, p = 0.035), but not with S89N polymorphism (p = 0.620). 27090416 2016
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE We conclude that urotensin-II is a locally released vasoactive mediator that may be an important regulator of blood flow particularly to the myocardium and may have a specific role in human atherosclerosis. 15476944 2004
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE We conclude that urotensin-II is a locally released vasoactive mediator that may be an important regulator of blood flow particularly to the myocardium and may have a specific role in human atherosclerosis. 15476944 2004
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.010 AlteredExpression disease BEFREE Using quantitative real-time RT-PCR we observed both increased U-II and GPR14 mRNA expression in tissue extracts from abdominal aortic aneurysms. 15306183 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.220 Biomarker disease RGD Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators. 15549273 2004
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Biomarker phenotype RGD Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. 17900760 2008
CUI: C0553980
Disease: Endomyocardial Fibrosis
Endomyocardial Fibrosis 		0.200 Biomarker phenotype RGD Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. 17184580 2007
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.030 Biomarker disease BEFREE Urinary hUII concentrations from patients with essential hypertension and those with renal tubular abnormality, but not with glomerular diseases, were significantly greater than those from normal individuals. 11725162 2001
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.040 AlteredExpression disease BEFREE Upregulation of the urotensin receptors and elevation of plasma U-II levels are thought to possibly play a role in the etiology of renal failure. 31518496 2019
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 GeneticVariation disease BEFREE To the best of our knowledge, for the first time in the literature, our study claims that there is an association between Thr21Met, and not between Ser89Asn polymorphisms in the UTS-II gene and BD. 23333481 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Thus, our data suggested an important effect of UII in hepatocellular carcinoma metastasis. 27988353 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 Biomarker disease BEFREE Thus, our data suggested an important effect of UII in hepatocellular carcinoma metastasis. 27988353 2017
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma 		0.030 Biomarker disease BEFREE Thus, UII and its receptor GPR14 exert a possible effect in the pathogenesis of pheochromocytoma. 17102097 2006
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma 		0.030 Biomarker disease BEFREE Thus, UII and its receptor GPR14 exert a possible effect in the pathogenesis of pheochromocytoma. 17102097 2006
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.020 Biomarker disease BEFREE This study was designed to investigate the effect of urantide, a UII receptor antagonist, on the structure and function of the right ventricle in PAH rat models by Doppler echocardiography. 29362961 2019